Multiple Sclerosis

Stem Cell > Multiple Sclerosis

Multiple sclerosis is a long term disease hitting human being at the age from 20 to 50 years. It is a demyelinating disease and affects the nerve cells insulating covers in the spinal cord and brain is damaged. The result is the disruption of the nervous system parts to communicate among them that eventually lead to physical, mental and psychiatric problems.

Cause

The primary cause of multiple sclerosis is an immune mediated attack that targets the myelin sheath components. The problem with myelin sheath is that it hinders communication among the neurons properly and acts as an insulator, among them.

Treatment

There is no complete treatment so far for multiple sclerosis, so far. It is because there is no viable treatment developed for abnormal immune response targeting, in multiple sclerosis. However, there are certain approaches followed by today, such as immune suppressants, copaxone, interferon, all acting towards blockage of immune responses in a non-specific manner, against the myelin sheath. These approaches help to reduce the disease severity, though they cannot repair the damage to the tissues of nervous system, which occurred already and so cannot completely cure multiple sclerosis.

Treatment with Stem Cells

There are certain stem cells that have the capability to stop the attack of myelin sheath to immune system, because of its immune regulatory property. The same cells also have the capability to help the affected neurons’ remyelination, which is the capability of myelin sheath re-generation. The University of Cambridge, currently is conducting the study and research, formal and clinical, with the help of mesenchymal stem cells towards multiple sclerosis treatment. So far the studies show that mesenchymal stem cells derived from umbilical cord tissue administration, show improvements in the patients of multiple sclerosis treatment.

Multiple sclerosis is treated with the adult stem cells derived from human umbilical cord tissues, such as allogeneic mesenchymal, at the Stem Cell Institute. Expansion of these stem cells is made possible at the laboratory of Medistem Panama.

Advantages of Using Stem Cells

Multiple sclerosis is possible to cure by using allogeneic umbilical cord tissue, derived the stem cells. Scientists and researchers are inclined to these stem cells for this benefit, for the following reasons.

  • The HUCT mesenchymal stem cells are well privileged with immune system and it does not demand matching with Human Leukocyte Antigen and so cell rejection is not an issue here.
  • These cells are selected for having the best anti-inflammatory activity, better capacity of immune modulation and enough capability for regeneration stimulation.
  • Allogeneic stem cells are flexible enough to get administer multiple times in uniform dosages, over the course of days, containing higher counts of cells.
  • An abundant mesenchymal stem cells supply can be provided by the umbilical cord tissue.
  • There is no need for collecting the same stem cells from the fat or hip bone of patients, which would be an unpleasant ordeal, especially for the parents and small children.
  • Mesenchymal stem cells are proved with growing evidence that the umbilical cord-derived mesenchymal stem cells are proved to be more robust compared to the other sources’ derived mesenchymal stem cells.
  • There is no need for chemotherapy drugs administration, such as Granulocyte-colony stimulating factor, towards bone marrow stimulation for granulocytes production, since the stem cells possess the capability to release them into the stream of blood.
  • These cells can be served as the starting materials used for the clinical trials of multiple sclerosis cellular products.

Acceptance by the Patient’s Body

The immune system of the body cannot recognize the mesenchymal stem cells derived from umbilical cord as foreign and so do not reject. According to the reports and statistics, the HUCT stem cells were never rejected, even in a single instance, even after administering for thousands of times.