Cerebral Palsy is often appeared in early childhood and it is a group of disorders of permanent disorders, with varied signs and symptoms. Some common symptoms are stiff muscles, poor coordination, weak muscles, sometimes also with vision, speaking, sensation, swallowing, speaking and hearing problems.
The root cause of the Cerebral Palsy is majorly from damage or abnormal development to the brain parts, which control posture, balance and movement. Advancement of the neuroscience attempts for better understanding of the brain development and greater progress is hoped towards its cure, by the researchers. The logic and key concept to understand and treat Cerebral Palsy is to explore and analyze the interconnection and function of the network of cells in the brain parts and the way all they work together.
Cerebral Palsy is harder to fully comprehend and is a difficult condition for treatment. Towards better treatment for the CP, there is a huge effort put on understanding it and achieve the present goal of reducing the symptoms, by limiting the damage of the brain.
Cerebral Palsy is treated traditionally with supportive medications, treatments and surgery and shows some relief. These treatments are usually, speech therapy, occupational therapy and physical therapy. There are other alternative and potential therapies that have capability to cure and allow the children to live near adult life lead. One of such potential therapies is the stem cell therapy. Many more efforts are given to make use of stem cells to treat and cure Cerebral Palsy.
Stem Cells for Cerebral Palsy
Stem cells are the cells that are multipotent and progenitor, having the properties of growth stimulation and imunomodulatory. Stem cell therapy to treat Cerebral Palsy is under rigorous research to determine its effectiveness. Some clinical trial tests are conducted by making use of the umbilical cord blood infusions towards stem cells introduction in the body.
Stem cells have the capability to develop the specific kind of cells of brain, by replacing the damaged cells of the same type. Theoretically, when stem cells placed into the body of a human being, they can stimulate a response mending the cells that are damaged. The same stem cells can also function to produce new brain cells and replace the cells that are damaged.
Treatment with Stem Cells
The potential treatment of Cerebral Palsy with the stem cells is stem cell transplantation is repairing and protecting the cells that are damaged, before they are lost completely, after turning useless resulting cell permanent damage. The treatment can potentially solve the issues of extent of mobility in children suffering from Cerebral Palsy. It is done through repairing the neurological defects, repair, regenerate and re-establish the balance lost in between various neurotrophic factors, by stimulating the endogenous stem cells.
What the Clinical Trails Say?
Clinical trials are conducted for the patients suffering from Cerebral Palsy and used autologous bone-marrow derived mononuclear cell (BMMNC). These cells are considered because of various reasons, such as their differentiation potential, efficacy, safety. After giving the specific stem cells in the form of five injections intrathecally, improvements are recorded and reported in the scale of Gross Motor Function Classification System, with marked motor, speech, cognitive and sensory amelioration. The same reports have also indicated better control of bowel and bladder with excellent tolerance.
Other clinical trials tested with the autologous umbilical cord blood stem cells and injection of Granulocyte Colony Stimulating Factor, in low dose, reported that the children have enough tolerance to the clinical procedure in good condition and showed greater improvement in the Gross Motor Function Classification System, specifying no side effects significant.
The present stem cell therapy has potential to reduce the Cerebral Palsy symptoms and increase the mobility in children, suffering with it.